Decreased Esophageal Distensibility in Children With Eosinophilic Esophagitis: Is Fibrosis Inevitable?
نویسندگان
چکیده
منابع مشابه
Esophageal subepithelial fibrosis in children with eosinophilic esophagitis.
OBJECTIVES Esophageal subepithelial fibrosis has been reported in adults with eosinophilic esophagitis (EE). Our goal was to determine the prevalence of esophageal fibrosis in children with EE, to determine whether it is specific for EE, and to correlate it with clinical and pathological features. PATIENTS AND METHODS Twenty-one children with EE, 7 with eosinophilic gastroenteritis, 6 with ga...
متن کاملPediatric eosinophilic esophagitis is associated with changes in esophageal microRNAs.
The incidence of eosinophilic esophagitis (EoE) has increased in the past several years, yet our understanding of its pathogenesis remains limited. To test the hypothesis that microRNAs (miRNAs) are altered in children with EoE, miRNAs were profiled in esophageal mucosa biopsies obtained from patients with active disease (n = 5) and healthy control subjects (n = 6). Fourteen miRNAs were signifi...
متن کاملEsophageal motility in eosinophilic esophagitis.
BACKGROUND Eosinophilic esophagitis (EoE) is characterized by eosinophilic infiltration of the esophagus and is a potential cause of dysphagia and food impaction, most commonly affecting young men. Esophageal manometry findings vary from normal motility to aperistalsis, simultaneous contractions, diffuse esophageal spasm, nutcracker esophagus or hypotonic lower esophageal sphincter (LES). It re...
متن کاملEsophageal subepithelial fibrosis and hyalinization are features of eosinophilic esophagitis.
BACKGROUND AND OBJECTIVE Eosinophilic esophagitis (EE) is characterized by marked esophageal mucosal eosinophilia on histological examination. Although the clinical and histological features of EE are increasingly recognized, the overlap of clinical symptoms and histological findings with gastroesophageal reflux disease (GERD) can lead to diagnostic difficulty. In children with EE we sought to ...
متن کاملEsophageal Subepithelial Fibrosis and Hyalinization Are Features of Eosinophilic Esophagitis
performed to 16 foods and 38 inhalant allergens. Patch testing to foods was also performed. IgE-mediated allergy was diagnosed if either serum-specific IgE or skinprick test results were positive, whereas non–IgE-mediated allergy was diagnosed if a positive patch test result was found. A streptavidin-based immunoassay was performed to determine the presence of cross-reactive carbohydrate determ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2018
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2018.03.059